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Research offers hope

Research offers hope

There is hope in the battle against drug-resistant drugs, though. For example, a newly discovered antibiotic, produced by bacteria from a cystic fibrosis patient, could be used to treat cases of drug-resistant tuberculosis (TB), according to a team of scientists from Cardiff University’s School of Biosciences and the University of Warwick.

The problem of antibiotic-resistant infections is pronounced in the treatment of TB; it is estimated that by 2040, more than a third of all TB cases in Russia, for example, could show resistance to the drugs currently used to fight the disease.

Among potential new drug sources is a group of the bacteria called Burkholderia that thrive in a wide range of natural habitats, but occasionally cause infection such as those within the lungs of people with cystic fibrosis. The microbes have adapted to these diverse environments in part by making potent antibiotics.

A team led by Professor Gregory L. Challis from the University of Warwick and Professor Eshwar Mahenthiralingam from Cardiff University set out to determine whether Burkholderia could potentially produce new antibiotics that could treat diseases such as drug-resistant TB.

They were assisted by Professor Julian Parkhill (Wellcome Trust Sanger Institute, Cambridge, UK) and Professor Stewart Cole (Global Health Institute, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland).

The team discovered that one particular species, Burkholderia gladioli, which was isolated from the sputum of a child with cystic fibrosis, produces an antibiotic they called gladiolin.

This compound is similar in structure to another antibiotic that has been investigated for its ability to jam bacterial cell machinery, but gladiolin is much more stable and could potentially be a better drug candidate. Further testing showed that the antibiotic blocked the growth of four drug-resistant TB strains.

Professor Mahenthiralingam said: “This work is a continuation of our research on Burkholderia bacteria as a new source of antibiotics, and it has shown that Burkholderia gladioli, which we have historically studied as lung infections in people with cystic fibrosis, can also produce potent drugs for global infectious diseases such as antibiotic resistant tuberculosis.

“Since this clinical testing process can take over a decade, it is vital we keep screening sources such as Burkholderia for other new antibiotics, and we hope that further research funding is made available to do this.”

The research was funded by Biotechnology and Biological Sciences Research Council (U.K.), the Wales Life Sciences Bridging Fund and a Marie Sklodowska-Curie Actions Fellowship.

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