New clinical study into R-ketamine use for Treatment Resistant Depression

A clinical study to evaluate the safety and efficacy of PCN-101 (R-ketamine) has entered a new phase. R-ketamine is a stereoisomer of ketamine being developed for therapeutic treatment of psychiatric disorders such as Treatment Resistant...

£45M to advance gene therapy treatment of chronic kidney diseases

The University of Bristol has secured a £45million deal to advance its ground-breaking gene therapy technology for chronic kidney diseases. The commitment, made by healthcare company Syncona Ltd to Bristol spin-out Purespring Therapeutics, aims to...

Colon Cancer Cells Use Mysterious RNA Strands to Avoid Cell Death

New study paves way for novel therapeutics Researchers from Case Western Reserve University School of Medicine have discovered how unusually long strands of RNA help colon cancer cells avoid death, allowing unregulated growth. Unlike other...

Looking for a partner for your biosimilar clinical trial?

BioKinetic Europe is one of the UK’s leading early phase clinical research organizations with experience in over 400 clinical trials.  Our Phase I portfolio comprises BE/BA studies, SAD/MAD/Proof of Concept, TQTc, DDI, vaccine and...

Biosimilars – What are the critical regulatory milestones during development and registration?

The ever increasing complexity of regulations and drug approval pathways has converted regulatory intelligence into one of the key assets during any kind of drug development. This situation is even more pronounced in the case...

The age of Cell Therapy

Industry that takes advantage of pioneering research. For a cutting-edge technology, cell therapy has a surprisingly long history. Indeed, the idea of injecting living cells into a patient originated in the nineteenth century. Although scientists’ early...

Critical Factor for Industrializing Cell Therapies:

Quality Attributes and Quality Assurance of the Manufacturing Raw Materials Slowly but progressively more Advanced Therapy Medicinal Products (ATMP), including Cell Therapy Products, are reaching the market and a significant number are getting closer to...

Growing the UK cell and gene therapy industry

Cell and gene therapies are at the very cutting-edge of medical research and the creation of the Cell Therapy Catapult’s state-of-the-art £55 million manufacturing centre at the Stevenage Bioscience Catalyst, will help Britain be...

Replace FBS with Human Platelet Lysate

The manufacture of clinical-grade cellular products often requires ex vivo culture and expansion of human cells. Fetal bovine serum (FBS) is frequently used as a supplement to basal cell culture media during expansion; however, its...

Product Characterization for Cell Therapy GMP Manufacturing

The specifications, QC and release testing of cell therapy products can make the difference between success and failure. Stefanos Theoharis, Suncana Kern and Christine Guenther, apceth GmbH & Co. KG All manufactured products require measurable parameters,...

Vericel: Improving multicellular therapy through advanced manufacturing

Founded in 1989, Vericel (formerly Aastrom Biosciences) is dedicated to the development of patient-specific expanded cellular therapies for use in the treatment of patients with severe diseases and conditions. The company currently markets two cell...

Bioscience Expertise, Training, and Equipment Access

Bioscience Technology is moving so quickly that radical approaches have to be taken to ensure researchers have sustainable access to cutting-edge expertise, equipment and training. The Bioscience Technology Facility is an exemplar which proves...

Climate Change – and the challenges facing mankind

Climate change is one of the biggest challenges facing mankind. Always has been, always will be, and that means that big changes lie ahead. Many of those changes will impact on the work of scientists...

Understanding climate change and infectious disease: is the one health movement enough?

In the coming decades, climate change is predicted to produce a range of direct and indirect impacts on both human and animal health. At the most basic level, rising temperatures and changes to rainfall...

Bolder Faster Stronger

How far can we go in the battle against illness? Earlier this year, Austrian researchers came up with the startling suggestion that life should be regarded as beginning at sixty five. Researchers at the International Institute...

Minister sounds an optimist note

Bioscience Journal asked Life Sciences Minister George Freeman to assess the progress being made. As the UK’s first ever minister for Life Sciences, I am determined to ensure that Britain remains the best place in...