A novel method of detecting viruses in very small volumes has been developed in a collaboration between scientists at Swansea University, Biovici Ltd and the National Physical Laboratory.
Their work – published in Advanced NanoBiomed Research – follows a successful Innovate UK project developing graphene for use in biosensors, devices that can detect tiny levels of disease markers.
For many parts of the world that do not have access to high-tech labs found in hospitals, detecting viruses such as hepatitis C (HCV) could save millions of preventable deaths worldwide. In addition, biosensors like these could be used at the point-of-care – opening effective healthcare in difficult-to-reach settings.
What makes the detection of viruses in such small volumes possible is the use of graphene. It’s extremely thin – only one atom thick – making it very sensitive to anything that attaches to it. By carefully controlling its surface, scientists at Swansea University were able to make the surface of graphene sensitive to the HCV virus. These measurements were done with graphene specialists at the National Physical Laboratory.
In the future, it is hoped that multiple biosensors can be developed onto a single chip, which could be used to detect different types of dangerous viruses or disease markers from a single measurement.
Ffion Walters, Innovation Technologist at Swansea, said: “Highly sensitive and simplistic sensors have never been more in demand with regards point-of-care applications. This collaborative project has allowed us to realise proof-of-concept real-time sensors for HCV, which could be especially beneficial in resource-limited settings or for difficult-to-reach populations.”
Professor Owen Guy, Head of Chemistry at the University, added: At Swansea University, we have now developed graphene-based biosensors for both Hepatitis B and C. This is a major step forward to a future single point of care test”
Dr Olga Kazakova, NPL Fellow Quantum Materials & Sensors, concluded: “Participation in this project allowed us to further develop our metrological validation facilities and apply them to the characterisation of graphene biosensors and aid in solving an important challenge in the health sector.”