I. Introduction

As drug discovery continues to evolve, innovative tools and resources are essential for unlocking the potential of emerging compounds, and that’s where Inspiralis Limited comes in. As a leading biotech company specializing in DNA modifying enzymes and substrates, Inspiralis delivers high-quality products and services that support preclinical development of anti-infective and anti-cancer compounds. Established in 2008 as a spinout from Professor Tony Maxwell’s group at the John Innes Centre (Norwich, UK), Inspiralis has quickly established itself as a reliable collaborator and partner in the research and drug discovery community. Their location inside the Innovation Centre on the Norwich Research Park ensures they are at the forefront of cutting-edge research and development.

II. The World of Inspiralis Limited

Inspiralis’ product offerings include DNA topoisomerases, other DNA modifying enzymes, and DNA substrates, either alone or in easy-to-use assay kits. They are also adding to their current product portfolio, with new helicases and better catenated DNA substrates coming soon. Inspiralis’s aim is to provide pharmaceutical companies, academic researchers and others involved in drug development, with the necessary tools to aid in the preclinical development of novel anti-infective and anti-cancer compounds.

Dr Natassja Bush, Joint Managing Director at Inspiralis Limited explained “To support drug discovery and research, we complement our product offerings with contract research services including inhibitor screening, hit-to-lead/lead optimization evaluation (in the form of IC50’s), mode of action studies, and custom protein production services. These resources also support researchers investigating biological processes or doing more fundamental research”. In terms of mode of action studies, their tools and resources incorporate complex biochemical assays, biophysical analysis, and crystallography to gain critical insights into how novel compounds work. They are also able to create and purify clinically relevant resistant enzyme variants, accessory proteins or even enzymes from alternative species to further delve into mode of action of compounds or look for cross-reactivity with other targets.

Inspiralis’s reach extends globally, with the ability to ship their products to pharmaceutical companies, other biotech firms, and academic groups worldwide. Natassja’s co-director, Dr Nicolas Burton, said “Researchers rely on our expertise and high-quality products to drive their discoveries forward, confident in the knowledge that they are utilizing the finest resources available”.

III. The Inspiralis Difference

What makes Inspiralis stand out is their customer service and commitment to quality. Natassja said “At Inspiralis, we believe that our team is the cornerstone of our success. Our experts leverage a wealth of experience and knowledge to provide the highest level of support and guidance to researchers. We have cultivated meaningful collaborations with academic groups at the John Innes Centre and the University of East Anglia, ensuring that we stay at the cutting edge of scientific advancements. Our support and guidance ensure that researchers achieve optimal results, employing personalized assistance with our tools and services”.

“Consistency and excellence are at the heart of Inspiralis. Our commitment to providing high-quality products with meticulous attention to detail ensures that you receive exceptional products and services time and time again. And our supportive and collaborative approach ensures that we develop long-lasting relationships with our partners”.

IV. Conclusion

Inspiralis Limited is the premier provider in the field of DNA modifying enzymes and DNA substrates, offering a range of products and services that support preclinical development in drug discovery, and push the boundaries of scientific knowledge. For 15 years they have supported a wide range of pharmaceutical companies, biotech’s and academics in the development of new antibiotics and anti-cancer drugs. As a trusted partner in scientific endeavours, they provide top-tier products, unparalleled support, and a genuine commitment to advancing scientific research and supporting drug discovery.

T: +44 (0)1603673590

E: contact@inspiralis.co.uk